GrippeCanadaV3, Main, Exploration, bibRecord, 000046

Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network).

Identifieur interne : 000046 ( Main/Exploration ); précédent : 000045; suivant : 000047

Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network).

Auteurs : Michaela K. Nichols [Canada] ; Melissa K. Andrew [Canada] ; Todd F. Hatchette [Canada] ; Ardith Ambrose [Canada] ; Guy Boivin [Canada] ; William Bowie [Canada] ; Ayman Chit [Canada] ; Gael Dos Santos [Belgique] ; May Elsherif [Canada] ; Karen Green [Canada] ; Francois Haguinet [Belgique] ; Scott A. Halperin [Canada] ; Barbara Ibarguchi [Canada] ; Jennie Johnstone [Canada] ; Kevin Katz [Canada] ; Phillipe Lagacé-Wiens [Canada] ; Joanne M. Langley [Canada] ; Jason Leblanc [Canada] ; Mark Loeb [Canada] ; Donna Mackinnon-Cameron [Canada] ; Anne Mccarthy [Canada] ; Janet E. Mcelhaney [Canada] ; Allison Mcgeer [Canada] ; Andre Poirier [Canada] ; Jeff Powis [Canada] ; David Richardson [Canada] ; Anne Schuind [États-Unis] ; Makeda Semret [Canada] ; Vivek Shinde [États-Unis] ; Stephanie Smith [Canada] ; Daniel Smyth [Canada] ; Grant Stiver [Canada] ; Geoffrey Taylor [Canada] ; Sylvie Trottier [Canada] ; Louis Valiquette [Canada] ; Duncan Webster [Canada] ; Lingyun Ye [Canada] ; Shelly A. Mcneil [Canada]

Source :

Vaccine [ 1873-2518 ] ; 2018.

RBID : pubmed:29548608

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Canada (épidémiologie), Comorbidité, Facteurs de risque, Femelle, Grippe humaine (), Grippe humaine (histoire), Grippe humaine (épidémiologie), Histoire du 21ème siècle, Hospitalisation, Humains, Mâle, Programmes de vaccination, Saisons, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la santé publique, Vaccination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (), Virus de la grippe A (immunologie), Études cas-témoins.
MESH :
- administration et posologie : Vaccins antigrippaux.
- histoire : Grippe humaine.
- immunologie : Vaccins antigrippaux, Virus de la grippe A.
- épidémiologie : Canada, Grippe humaine.
- Adulte d'âge moyen, Comorbidité, Facteurs de risque, Femelle, Grippe humaine, Histoire du 21ème siècle, Hospitalisation, Humains, Mâle, Programmes de vaccination, Saisons, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la santé publique, Vaccination, Virus de la grippe A, Études cas-témoins.
Wicri :
- geographic : Canada.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Canada (epidemiology), Case-Control Studies, Comorbidity, Female, History, 21st Century, Hospitalization, Humans, Immunization Programs, Influenza A virus (classification), Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (history), Influenza, Human (prevention & control), Male, Middle Aged, Outcome Assessment, Health Care, Public Health Surveillance, Risk Factors, Seasons, Vaccination.
MESH :
- chemical , administration & dosage : Influenza Vaccines.
- geographic , epidemiology : Canada.
- classification : Influenza A virus.
- epidemiology : Influenza, Human.
- history : Influenza, Human.
- immunology : Influenza A virus, Influenza Vaccines.
- prevention & control : Influenza, Human.
- Aged, Aged, 80 and over, Case-Control Studies, Comorbidity, Female, History, 21st Century, Hospitalization, Humans, Immunization Programs, Male, Middle Aged, Outcome Assessment, Health Care, Public Health Surveillance, Risk Factors, Seasons, Vaccination.

Abstract

BACKGROUND

Ongoing assessment of influenza vaccine effectiveness (VE) is critical to inform public health policy. This study aimed to determine the VE of trivalent influenza vaccine (TIV) for preventing influenza-related hospitalizations and other serious outcomes over three consecutive influenza seasons.

METHODS

The Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN) conducted active surveillance for influenza in adults ≥16 years (y) of age during the 2011/2012, 2012/2013 and 2013/2014 seasons in hospitals across Canada. A test-negative design was employed: cases were polymerase chain reaction (PCR)-positive for influenza; controls were PCR-negative for influenza and were matched to cases by date, admission site, and age (≥65 y or <65 y). All cases and controls had demographic and clinical characteristics (including influenza immunization status) obtained from the medical record. VE was estimated as 1-OR (odds ratio) in vaccinated vs. unvaccinated patients × 100%. The primary outcome was VE of TIV for preventing laboratory-confirmed influenza-related hospitalization; secondary outcomes included VE of TIV for preventing influenza-related intensive care unit (ICU) admission/mechanical ventilation, and influenza-related death.

RESULTS

Overall, 3394 cases and 4560 controls were enrolled; 2078 (61.2%) cases and 2939 (64.5%) controls were ≥65 y. Overall matched, adjusted VE was 41.7% (95% Confidence Interval (CI): 34.4-48.3%); corresponding VE in adults ≥65 y was 39.3% (95% CI: 29.4-47.8%) and 48.0% (95% CI: 37.5-56.7%) in adults <65 y, respectively. VE for preventing influenza-related ICU admission/mechanical ventilation in all ages was 54.1% (95% CI: 39.8-65.0%); in adults ≥65 y, VE for preventing influenza-related death was 74.5% (95% CI: 44.0-88.4%).

CONCLUSIONS

While effectiveness of TIV to prevent serious outcomes varies year to year, we demonstrate a statistically significant and clinically important TIV VE for preventing hospitalization and other serious outcomes over three seasons. Public health messaging should highlight the overall benefit of influenza vaccines over time while acknowledging year to year variability. ClinicalTrials.gov Identifier: NCT01517191.

DOI: 10.1016/j.vaccine.2018.02.093
PubMed: 29548608

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000051
to stream Main, to step Curation: 000051

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network).</title>
<author><name sortKey="Nichols, Michaela K" sort="Nichols, Michaela K" uniqKey="Nichols M" first="Michaela K" last="Nichols">Michaela K. Nichols</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hatchette, Todd F" sort="Hatchette, Todd F" uniqKey="Hatchette T" first="Todd F" last="Hatchette">Todd F. Hatchette</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ambrose, Ardith" sort="Ambrose, Ardith" uniqKey="Ambrose A" first="Ardith" last="Ambrose">Ardith Ambrose</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Québec, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Québec, Québec, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bowie, William" sort="Bowie, William" uniqKey="Bowie W" first="William" last="Bowie">William Bowie</name>
<affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of British Columbia, Vancouver, British Columbia</wicri:regionArea>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chit, Ayman" sort="Chit, Ayman" uniqKey="Chit A" first="Ayman" last="Chit">Ayman Chit</name>
<affiliation wicri:level="4"><nlm:affiliation>Sanofi Pasteur, Swiftwater, PA, USA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Sanofi Pasteur, Swiftwater, PA, USA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos, Gael" sort="Dos Santos, Gael" uniqKey="Dos Santos G" first="Gael" last="Dos Santos">Gael Dos Santos</name>
<affiliation wicri:level="3"><nlm:affiliation>Business & Decision Life Sciences, Bruxelles, Belgium(2).</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Belgique</country>
<wicri:regionArea>Business & Decision Life Sciences, Bruxelles</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elsherif, May" sort="Elsherif, May" uniqKey="Elsherif M" first="May" last="Elsherif">May Elsherif</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name>
<affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haguinet, Francois" sort="Haguinet, Francois" uniqKey="Haguinet F" first="Francois" last="Haguinet">Francois Haguinet</name>
<affiliation wicri:level="1"><nlm:affiliation>GSK, Wavre, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>GSK, Wavre</wicri:regionArea>
<wicri:noRegion>Wavre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Halperin, Scott A" sort="Halperin, Scott A" uniqKey="Halperin S" first="Scott A" last="Halperin">Scott A. Halperin</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibarguchi, Barbara" sort="Ibarguchi, Barbara" uniqKey="Ibarguchi B" first="Barbara" last="Ibarguchi">Barbara Ibarguchi</name>
<affiliation wicri:level="1"><nlm:affiliation>GSK, Mississauga, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>GSK, Mississauga, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Johnstone, Jennie" sort="Johnstone, Jennie" uniqKey="Johnstone J" first="Jennie" last="Johnstone">Jennie Johnstone</name>
<affiliation wicri:level="4"><nlm:affiliation>McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McMaster University, Hamilton, Ontario</wicri:regionArea>
<orgName type="university">Université McMaster</orgName>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name>
<affiliation wicri:level="1"><nlm:affiliation>North York General Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>North York General Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lagace Wiens, Phillipe" sort="Lagace Wiens, Phillipe" uniqKey="Lagace Wiens P" first="Phillipe" last="Lagacé-Wiens">Phillipe Lagacé-Wiens</name>
<affiliation wicri:level="1"><nlm:affiliation>St. Boniface Hospital, Winnipeg, Manitoba, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>St. Boniface Hospital, Winnipeg, Manitoba</wicri:regionArea>
<wicri:noRegion>Manitoba</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Langley, Joanne M" sort="Langley, Joanne M" uniqKey="Langley J" first="Joanne M" last="Langley">Joanne M. Langley</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leblanc, Jason" sort="Leblanc, Jason" uniqKey="Leblanc J" first="Jason" last="Leblanc">Jason Leblanc</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
<affiliation wicri:level="4"><nlm:affiliation>McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McMaster University, Hamilton, Ontario</wicri:regionArea>
<orgName type="university">Université McMaster</orgName>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mackinnon Cameron, Donna" sort="Mackinnon Cameron, Donna" uniqKey="Mackinnon Cameron D" first="Donna" last="Mackinnon-Cameron">Donna Mackinnon-Cameron</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name>
<affiliation wicri:level="1"><nlm:affiliation>The Ottawa Hospital, Ottawa, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Ottawa Hospital, Ottawa, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E" last="Mcelhaney">Janet E. Mcelhaney</name>
<affiliation wicri:level="1"><nlm:affiliation>Health Sciences North Research Institute, Sudbury, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Health Sciences North Research Institute, Sudbury, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name>
<affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poirier, Andre" sort="Poirier, Andre" uniqKey="Poirier A" first="Andre" last="Poirier">Andre Poirier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Intégré Universitaire de santé et services sociaux, Quebec, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Intégré Universitaire de santé et services sociaux, Quebec, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name>
<affiliation wicri:level="1"><nlm:affiliation>Michael Garron Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Michael Garron Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name>
<affiliation wicri:level="1"><nlm:affiliation>William Osler Health System, Brampton, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>William Osler Health System, Brampton, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuind, Anne" sort="Schuind, Anne" uniqKey="Schuind A" first="Anne" last="Schuind">Anne Schuind</name>
<affiliation wicri:level="2"><nlm:affiliation>GSK, Rockville, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>GSK, Rockville, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Semret, Makeda" sort="Semret, Makeda" uniqKey="Semret M" first="Makeda" last="Semret">Makeda Semret</name>
<affiliation wicri:level="4"><nlm:affiliation>McGill University, Montreal, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill University, Montreal, Québec</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name>
<affiliation wicri:level="2"><nlm:affiliation>GSK, King of Prussia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>GSK, King of Prussia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Stephanie" sort="Smith, Stephanie" uniqKey="Smith S" first="Stephanie" last="Smith">Stephanie Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Alberta Hospital, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Alberta Hospital, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smyth, Daniel" sort="Smyth, Daniel" uniqKey="Smyth D" first="Daniel" last="Smyth">Daniel Smyth</name>
<affiliation wicri:level="1"><nlm:affiliation>The Moncton Hospital, Moncton, New Brunswick, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Moncton Hospital, Moncton, New Brunswick</wicri:regionArea>
<wicri:noRegion>New Brunswick</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stiver, Grant" sort="Stiver, Grant" uniqKey="Stiver G" first="Grant" last="Stiver">Grant Stiver</name>
<affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of British Columbia, Vancouver, British Columbia</wicri:regionArea>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Geoffrey" sort="Taylor, Geoffrey" uniqKey="Taylor G" first="Geoffrey" last="Taylor">Geoffrey Taylor</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Alberta Hospital, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Alberta Hospital, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trottier, Sylvie" sort="Trottier, Sylvie" uniqKey="Trottier S" first="Sylvie" last="Trottier">Sylvie Trottier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Québec, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Québec, Québec, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Valiquette, Louis" sort="Valiquette, Louis" uniqKey="Valiquette L" first="Louis" last="Valiquette">Louis Valiquette</name>
<affiliation wicri:level="1"><nlm:affiliation>Université de Sherbrooke, Sherbrooke, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Université de Sherbrooke, Sherbrooke, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Webster, Duncan" sort="Webster, Duncan" uniqKey="Webster D" first="Duncan" last="Webster">Duncan Webster</name>
<affiliation wicri:level="1"><nlm:affiliation>Horizon Health, Saint John, New Brunswick, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Horizon Health, Saint John, New Brunswick</wicri:regionArea>
<wicri:noRegion>New Brunswick</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ye, Lingyun" sort="Ye, Lingyun" uniqKey="Ye L" first="Lingyun" last="Ye">Lingyun Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcneil, Shelly A" sort="Mcneil, Shelly A" uniqKey="Mcneil S" first="Shelly A" last="Mcneil">Shelly A. Mcneil</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address: shelly.mcneil@nshealth.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29548608</idno>
<idno type="pmid">29548608</idno>
<idno type="doi">10.1016/j.vaccine.2018.02.093</idno>
<idno type="wicri:Area/Main/Corpus">000051</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000051</idno>
<idno type="wicri:Area/Main/Curation">000051</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000051</idno>
<idno type="wicri:Area/Main/Exploration">000051</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network).</title>
<author><name sortKey="Nichols, Michaela K" sort="Nichols, Michaela K" uniqKey="Nichols M" first="Michaela K" last="Nichols">Michaela K. Nichols</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hatchette, Todd F" sort="Hatchette, Todd F" uniqKey="Hatchette T" first="Todd F" last="Hatchette">Todd F. Hatchette</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ambrose, Ardith" sort="Ambrose, Ardith" uniqKey="Ambrose A" first="Ardith" last="Ambrose">Ardith Ambrose</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Québec, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Québec, Québec, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bowie, William" sort="Bowie, William" uniqKey="Bowie W" first="William" last="Bowie">William Bowie</name>
<affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of British Columbia, Vancouver, British Columbia</wicri:regionArea>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chit, Ayman" sort="Chit, Ayman" uniqKey="Chit A" first="Ayman" last="Chit">Ayman Chit</name>
<affiliation wicri:level="4"><nlm:affiliation>Sanofi Pasteur, Swiftwater, PA, USA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Sanofi Pasteur, Swiftwater, PA, USA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos, Gael" sort="Dos Santos, Gael" uniqKey="Dos Santos G" first="Gael" last="Dos Santos">Gael Dos Santos</name>
<affiliation wicri:level="3"><nlm:affiliation>Business & Decision Life Sciences, Bruxelles, Belgium(2).</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Belgique</country>
<wicri:regionArea>Business & Decision Life Sciences, Bruxelles</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elsherif, May" sort="Elsherif, May" uniqKey="Elsherif M" first="May" last="Elsherif">May Elsherif</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name>
<affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haguinet, Francois" sort="Haguinet, Francois" uniqKey="Haguinet F" first="Francois" last="Haguinet">Francois Haguinet</name>
<affiliation wicri:level="1"><nlm:affiliation>GSK, Wavre, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>GSK, Wavre</wicri:regionArea>
<wicri:noRegion>Wavre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Halperin, Scott A" sort="Halperin, Scott A" uniqKey="Halperin S" first="Scott A" last="Halperin">Scott A. Halperin</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibarguchi, Barbara" sort="Ibarguchi, Barbara" uniqKey="Ibarguchi B" first="Barbara" last="Ibarguchi">Barbara Ibarguchi</name>
<affiliation wicri:level="1"><nlm:affiliation>GSK, Mississauga, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>GSK, Mississauga, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Johnstone, Jennie" sort="Johnstone, Jennie" uniqKey="Johnstone J" first="Jennie" last="Johnstone">Jennie Johnstone</name>
<affiliation wicri:level="4"><nlm:affiliation>McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McMaster University, Hamilton, Ontario</wicri:regionArea>
<orgName type="university">Université McMaster</orgName>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name>
<affiliation wicri:level="1"><nlm:affiliation>North York General Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>North York General Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lagace Wiens, Phillipe" sort="Lagace Wiens, Phillipe" uniqKey="Lagace Wiens P" first="Phillipe" last="Lagacé-Wiens">Phillipe Lagacé-Wiens</name>
<affiliation wicri:level="1"><nlm:affiliation>St. Boniface Hospital, Winnipeg, Manitoba, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>St. Boniface Hospital, Winnipeg, Manitoba</wicri:regionArea>
<wicri:noRegion>Manitoba</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Langley, Joanne M" sort="Langley, Joanne M" uniqKey="Langley J" first="Joanne M" last="Langley">Joanne M. Langley</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leblanc, Jason" sort="Leblanc, Jason" uniqKey="Leblanc J" first="Jason" last="Leblanc">Jason Leblanc</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
<affiliation wicri:level="4"><nlm:affiliation>McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McMaster University, Hamilton, Ontario</wicri:regionArea>
<orgName type="university">Université McMaster</orgName>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mackinnon Cameron, Donna" sort="Mackinnon Cameron, Donna" uniqKey="Mackinnon Cameron D" first="Donna" last="Mackinnon-Cameron">Donna Mackinnon-Cameron</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name>
<affiliation wicri:level="1"><nlm:affiliation>The Ottawa Hospital, Ottawa, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Ottawa Hospital, Ottawa, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E" last="Mcelhaney">Janet E. Mcelhaney</name>
<affiliation wicri:level="1"><nlm:affiliation>Health Sciences North Research Institute, Sudbury, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Health Sciences North Research Institute, Sudbury, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name>
<affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poirier, Andre" sort="Poirier, Andre" uniqKey="Poirier A" first="Andre" last="Poirier">Andre Poirier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Intégré Universitaire de santé et services sociaux, Quebec, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Intégré Universitaire de santé et services sociaux, Quebec, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name>
<affiliation wicri:level="1"><nlm:affiliation>Michael Garron Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Michael Garron Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name>
<affiliation wicri:level="1"><nlm:affiliation>William Osler Health System, Brampton, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>William Osler Health System, Brampton, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuind, Anne" sort="Schuind, Anne" uniqKey="Schuind A" first="Anne" last="Schuind">Anne Schuind</name>
<affiliation wicri:level="2"><nlm:affiliation>GSK, Rockville, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>GSK, Rockville, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Semret, Makeda" sort="Semret, Makeda" uniqKey="Semret M" first="Makeda" last="Semret">Makeda Semret</name>
<affiliation wicri:level="4"><nlm:affiliation>McGill University, Montreal, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill University, Montreal, Québec</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name>
<affiliation wicri:level="2"><nlm:affiliation>GSK, King of Prussia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>GSK, King of Prussia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Stephanie" sort="Smith, Stephanie" uniqKey="Smith S" first="Stephanie" last="Smith">Stephanie Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Alberta Hospital, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Alberta Hospital, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smyth, Daniel" sort="Smyth, Daniel" uniqKey="Smyth D" first="Daniel" last="Smyth">Daniel Smyth</name>
<affiliation wicri:level="1"><nlm:affiliation>The Moncton Hospital, Moncton, New Brunswick, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>The Moncton Hospital, Moncton, New Brunswick</wicri:regionArea>
<wicri:noRegion>New Brunswick</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stiver, Grant" sort="Stiver, Grant" uniqKey="Stiver G" first="Grant" last="Stiver">Grant Stiver</name>
<affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of British Columbia, Vancouver, British Columbia</wicri:regionArea>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Geoffrey" sort="Taylor, Geoffrey" uniqKey="Taylor G" first="Geoffrey" last="Taylor">Geoffrey Taylor</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Alberta Hospital, Edmonton, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Alberta Hospital, Edmonton, Alberta</wicri:regionArea>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trottier, Sylvie" sort="Trottier, Sylvie" uniqKey="Trottier S" first="Sylvie" last="Trottier">Sylvie Trottier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Québec, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Québec, Québec, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Valiquette, Louis" sort="Valiquette, Louis" uniqKey="Valiquette L" first="Louis" last="Valiquette">Louis Valiquette</name>
<affiliation wicri:level="1"><nlm:affiliation>Université de Sherbrooke, Sherbrooke, Québec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Université de Sherbrooke, Sherbrooke, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Webster, Duncan" sort="Webster, Duncan" uniqKey="Webster D" first="Duncan" last="Webster">Duncan Webster</name>
<affiliation wicri:level="1"><nlm:affiliation>Horizon Health, Saint John, New Brunswick, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Horizon Health, Saint John, New Brunswick</wicri:regionArea>
<wicri:noRegion>New Brunswick</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ye, Lingyun" sort="Ye, Lingyun" uniqKey="Ye L" first="Lingyun" last="Ye">Lingyun Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcneil, Shelly A" sort="Mcneil, Shelly A" uniqKey="Mcneil S" first="Shelly A" last="Mcneil">Shelly A. Mcneil</name>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address: shelly.mcneil@nshealth.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea>
<wicri:noRegion>Nova Scotia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Vaccine</title>
<idno type="eISSN">1873-2518</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Canada (epidemiology)</term>
<term>Case-Control Studies</term>
<term>Comorbidity</term>
<term>Female</term>
<term>History, 21st Century</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Immunization Programs</term>
<term>Influenza A virus (classification)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (history)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Outcome Assessment, Health Care</term>
<term>Public Health Surveillance</term>
<term>Risk Factors</term>
<term>Seasons</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Canada (épidémiologie)</term>
<term>Comorbidité</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (histoire)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Histoire du 21ème siècle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Mâle</term>
<term>Programmes de vaccination</term>
<term>Saisons</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Surveillance de la santé publique</term>
<term>Vaccination</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A ()</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Canada</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
<term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Canada</term>
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Comorbidity</term>
<term>Female</term>
<term>History, 21st Century</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Immunization Programs</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Outcome Assessment, Health Care</term>
<term>Public Health Surveillance</term>
<term>Risk Factors</term>
<term>Seasons</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Comorbidité</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grippe humaine</term>
<term>Histoire du 21ème siècle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Mâle</term>
<term>Programmes de vaccination</term>
<term>Saisons</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Surveillance de la santé publique</term>
<term>Vaccination</term>
<term>Virus de la grippe A</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Ongoing assessment of influenza vaccine effectiveness (VE) is critical to inform public health policy. This study aimed to determine the VE of trivalent influenza vaccine (TIV) for preventing influenza-related hospitalizations and other serious outcomes over three consecutive influenza seasons.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>The Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN) conducted active surveillance for influenza in adults ≥16 years (y) of age during the 2011/2012, 2012/2013 and 2013/2014 seasons in hospitals across Canada. A test-negative design was employed: cases were polymerase chain reaction (PCR)-positive for influenza; controls were PCR-negative for influenza and were matched to cases by date, admission site, and age (≥65 y or <65 y). All cases and controls had demographic and clinical characteristics (including influenza immunization status) obtained from the medical record. VE was estimated as 1-OR (odds ratio) in vaccinated vs. unvaccinated patients × 100%. The primary outcome was VE of TIV for preventing laboratory-confirmed influenza-related hospitalization; secondary outcomes included VE of TIV for preventing influenza-related intensive care unit (ICU) admission/mechanical ventilation, and influenza-related death.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Overall, 3394 cases and 4560 controls were enrolled; 2078 (61.2%) cases and 2939 (64.5%) controls were ≥65 y. Overall matched, adjusted VE was 41.7% (95% Confidence Interval (CI): 34.4-48.3%); corresponding VE in adults ≥65 y was 39.3% (95% CI: 29.4-47.8%) and 48.0% (95% CI: 37.5-56.7%) in adults <65 y, respectively. VE for preventing influenza-related ICU admission/mechanical ventilation in all ages was 54.1% (95% CI: 39.8-65.0%); in adults ≥65 y, VE for preventing influenza-related death was 74.5% (95% CI: 44.0-88.4%).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>While effectiveness of TIV to prevent serious outcomes varies year to year, we demonstrate a statistically significant and clinically important TIV VE for preventing hospitalization and other serious outcomes over three seasons. Public health messaging should highlight the overall benefit of influenza vaccines over time while acknowledging year to year variability. ClinicalTrials.gov Identifier: NCT01517191.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29548608</PMID>
<DateCompleted><Year>2018</Year>
<Month>09</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>36</Volume>
<Issue>16</Issue>
<PubDate><Year>2018</Year>
<Month>04</Month>
<Day>12</Day>
</PubDate>
</JournalIssue>
<Title>Vaccine</Title>
<ISOAbbreviation>Vaccine</ISOAbbreviation>
</Journal>
<ArticleTitle>Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network).</ArticleTitle>
<Pagination><MedlinePgn>2166-2175</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0264-410X(18)30292-5</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2018.02.093</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Ongoing assessment of influenza vaccine effectiveness (VE) is critical to inform public health policy. This study aimed to determine the VE of trivalent influenza vaccine (TIV) for preventing influenza-related hospitalizations and other serious outcomes over three consecutive influenza seasons.</AbstractText>
<AbstractText Label="METHODS">The Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN) conducted active surveillance for influenza in adults ≥16 years (y) of age during the 2011/2012, 2012/2013 and 2013/2014 seasons in hospitals across Canada. A test-negative design was employed: cases were polymerase chain reaction (PCR)-positive for influenza; controls were PCR-negative for influenza and were matched to cases by date, admission site, and age (≥65 y or <65 y). All cases and controls had demographic and clinical characteristics (including influenza immunization status) obtained from the medical record. VE was estimated as 1-OR (odds ratio) in vaccinated vs. unvaccinated patients × 100%. The primary outcome was VE of TIV for preventing laboratory-confirmed influenza-related hospitalization; secondary outcomes included VE of TIV for preventing influenza-related intensive care unit (ICU) admission/mechanical ventilation, and influenza-related death.</AbstractText>
<AbstractText Label="RESULTS">Overall, 3394 cases and 4560 controls were enrolled; 2078 (61.2%) cases and 2939 (64.5%) controls were ≥65 y. Overall matched, adjusted VE was 41.7% (95% Confidence Interval (CI): 34.4-48.3%); corresponding VE in adults ≥65 y was 39.3% (95% CI: 29.4-47.8%) and 48.0% (95% CI: 37.5-56.7%) in adults <65 y, respectively. VE for preventing influenza-related ICU admission/mechanical ventilation in all ages was 54.1% (95% CI: 39.8-65.0%); in adults ≥65 y, VE for preventing influenza-related death was 74.5% (95% CI: 44.0-88.4%).</AbstractText>
<AbstractText Label="CONCLUSIONS">While effectiveness of TIV to prevent serious outcomes varies year to year, we demonstrate a statistically significant and clinically important TIV VE for preventing hospitalization and other serious outcomes over three seasons. Public health messaging should highlight the overall benefit of influenza vaccines over time while acknowledging year to year variability. ClinicalTrials.gov Identifier: NCT01517191.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nichols</LastName>
<ForeName>Michaela K</ForeName>
<Initials>MK</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Andrew</LastName>
<ForeName>Melissa K</ForeName>
<Initials>MK</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hatchette</LastName>
<ForeName>Todd F</ForeName>
<Initials>TF</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ambrose</LastName>
<ForeName>Ardith</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boivin</LastName>
<ForeName>Guy</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Québec, Québec, Québec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bowie</LastName>
<ForeName>William</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chit</LastName>
<ForeName>Ayman</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Sanofi Pasteur, Swiftwater, PA, USA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dos Santos</LastName>
<ForeName>Gael</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Business & Decision Life Sciences, Bruxelles, Belgium(2).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>ElSherif</LastName>
<ForeName>May</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Green</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Mount Sinai Hospital, Toronto, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Haguinet</LastName>
<ForeName>Francois</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>GSK, Wavre, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Halperin</LastName>
<ForeName>Scott A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ibarguchi</LastName>
<ForeName>Barbara</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>GSK, Mississauga, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnstone</LastName>
<ForeName>Jennie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Katz</LastName>
<ForeName>Kevin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>North York General Hospital, Toronto, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lagacé-Wiens</LastName>
<ForeName>Phillipe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>St. Boniface Hospital, Winnipeg, Manitoba, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langley</LastName>
<ForeName>Joanne M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>LeBlanc</LastName>
<ForeName>Jason</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loeb</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>MacKinnon-Cameron</LastName>
<ForeName>Donna</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McCarthy</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>The Ottawa Hospital, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McElhaney</LastName>
<ForeName>Janet E</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Health Sciences North Research Institute, Sudbury, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McGeer</LastName>
<ForeName>Allison</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Mount Sinai Hospital, Toronto, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Poirier</LastName>
<ForeName>Andre</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre Intégré Universitaire de santé et services sociaux, Quebec, Quebec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Powis</LastName>
<ForeName>Jeff</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Michael Garron Hospital, Toronto, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Richardson</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>William Osler Health System, Brampton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schuind</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>GSK, Rockville, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Semret</LastName>
<ForeName>Makeda</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>McGill University, Montreal, Québec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shinde</LastName>
<ForeName>Vivek</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>GSK, King of Prussia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>Stephanie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>University of Alberta Hospital, Edmonton, Alberta, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smyth</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>The Moncton Hospital, Moncton, New Brunswick, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stiver</LastName>
<ForeName>Grant</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Taylor</LastName>
<ForeName>Geoffrey</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>University of Alberta Hospital, Edmonton, Alberta, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Trottier</LastName>
<ForeName>Sylvie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Québec, Québec, Québec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Valiquette</LastName>
<ForeName>Louis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Université de Sherbrooke, Sherbrooke, Québec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Webster</LastName>
<ForeName>Duncan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Horizon Health, Saint John, New Brunswick, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Lingyun</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McNeil</LastName>
<ForeName>Shelly A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address: shelly.mcneil@nshealth.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Serious Outcomes Surveillance Network of the Canadian Immunization Research Network (CIRN), the Toronto Invasive Bacterial Diseases Network (TIBDN)</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT01517191</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><Agency>CIHR</Agency>
<Country>Canada</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016456">Historical Article</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>03</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Vaccine</MedlineTA>
<NlmUniqueID>8406899</NlmUniqueID>
<ISSNLinking>0264-410X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049674" MajorTopicYN="N">History, 21st Century</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="Y">Hospitalization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017589" MajorTopicYN="N">Immunization Programs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000266" MajorTopicYN="N">history</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017063" MajorTopicYN="N">Outcome Assessment, Health Care</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D062486" MajorTopicYN="N">Public Health Surveillance</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012621" MajorTopicYN="Y">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Effectiveness</Keyword>
<Keyword MajorTopicYN="Y">Hospitalization</Keyword>
<Keyword MajorTopicYN="Y">Influenza vaccine</Keyword>
<Keyword MajorTopicYN="Y">Serious outcomes</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>11</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>02</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>02</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>3</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>9</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>3</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29548608</ArticleId>
<ArticleId IdType="pii">S0264-410X(18)30292-5</ArticleId>
<ArticleId IdType="doi">10.1016/j.vaccine.2018.02.093</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Belgique</li>
<li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
<li>Québec</li>
<li>Région de Bruxelles-Capitale</li>
</region>
<settlement><li>Bruxelles</li>
<li>Hamilton (Ontario)</li>
<li>Montréal</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université McMaster</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Nichols, Michaela K" sort="Nichols, Michaela K" uniqKey="Nichols M" first="Michaela K" last="Nichols">Michaela K. Nichols</name>
</noRegion>
<name sortKey="Ambrose, Ardith" sort="Ambrose, Ardith" uniqKey="Ambrose A" first="Ardith" last="Ambrose">Ardith Ambrose</name>
<name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name>
<name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name>
<name sortKey="Bowie, William" sort="Bowie, William" uniqKey="Bowie W" first="William" last="Bowie">William Bowie</name>
<name sortKey="Chit, Ayman" sort="Chit, Ayman" uniqKey="Chit A" first="Ayman" last="Chit">Ayman Chit</name>
<name sortKey="Elsherif, May" sort="Elsherif, May" uniqKey="Elsherif M" first="May" last="Elsherif">May Elsherif</name>
<name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name>
<name sortKey="Halperin, Scott A" sort="Halperin, Scott A" uniqKey="Halperin S" first="Scott A" last="Halperin">Scott A. Halperin</name>
<name sortKey="Hatchette, Todd F" sort="Hatchette, Todd F" uniqKey="Hatchette T" first="Todd F" last="Hatchette">Todd F. Hatchette</name>
<name sortKey="Ibarguchi, Barbara" sort="Ibarguchi, Barbara" uniqKey="Ibarguchi B" first="Barbara" last="Ibarguchi">Barbara Ibarguchi</name>
<name sortKey="Johnstone, Jennie" sort="Johnstone, Jennie" uniqKey="Johnstone J" first="Jennie" last="Johnstone">Jennie Johnstone</name>
<name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name>
<name sortKey="Lagace Wiens, Phillipe" sort="Lagace Wiens, Phillipe" uniqKey="Lagace Wiens P" first="Phillipe" last="Lagacé-Wiens">Phillipe Lagacé-Wiens</name>
<name sortKey="Langley, Joanne M" sort="Langley, Joanne M" uniqKey="Langley J" first="Joanne M" last="Langley">Joanne M. Langley</name>
<name sortKey="Leblanc, Jason" sort="Leblanc, Jason" uniqKey="Leblanc J" first="Jason" last="Leblanc">Jason Leblanc</name>
<name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name>
<name sortKey="Mackinnon Cameron, Donna" sort="Mackinnon Cameron, Donna" uniqKey="Mackinnon Cameron D" first="Donna" last="Mackinnon-Cameron">Donna Mackinnon-Cameron</name>
<name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name>
<name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E" last="Mcelhaney">Janet E. Mcelhaney</name>
<name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name>
<name sortKey="Mcneil, Shelly A" sort="Mcneil, Shelly A" uniqKey="Mcneil S" first="Shelly A" last="Mcneil">Shelly A. Mcneil</name>
<name sortKey="Poirier, Andre" sort="Poirier, Andre" uniqKey="Poirier A" first="Andre" last="Poirier">Andre Poirier</name>
<name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name>
<name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name>
<name sortKey="Semret, Makeda" sort="Semret, Makeda" uniqKey="Semret M" first="Makeda" last="Semret">Makeda Semret</name>
<name sortKey="Smith, Stephanie" sort="Smith, Stephanie" uniqKey="Smith S" first="Stephanie" last="Smith">Stephanie Smith</name>
<name sortKey="Smyth, Daniel" sort="Smyth, Daniel" uniqKey="Smyth D" first="Daniel" last="Smyth">Daniel Smyth</name>
<name sortKey="Stiver, Grant" sort="Stiver, Grant" uniqKey="Stiver G" first="Grant" last="Stiver">Grant Stiver</name>
<name sortKey="Taylor, Geoffrey" sort="Taylor, Geoffrey" uniqKey="Taylor G" first="Geoffrey" last="Taylor">Geoffrey Taylor</name>
<name sortKey="Trottier, Sylvie" sort="Trottier, Sylvie" uniqKey="Trottier S" first="Sylvie" last="Trottier">Sylvie Trottier</name>
<name sortKey="Valiquette, Louis" sort="Valiquette, Louis" uniqKey="Valiquette L" first="Louis" last="Valiquette">Louis Valiquette</name>
<name sortKey="Webster, Duncan" sort="Webster, Duncan" uniqKey="Webster D" first="Duncan" last="Webster">Duncan Webster</name>
<name sortKey="Ye, Lingyun" sort="Ye, Lingyun" uniqKey="Ye L" first="Lingyun" last="Ye">Lingyun Ye</name>
</country>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Dos Santos, Gael" sort="Dos Santos, Gael" uniqKey="Dos Santos G" first="Gael" last="Dos Santos">Gael Dos Santos</name>
</region>
<name sortKey="Haguinet, Francois" sort="Haguinet, Francois" uniqKey="Haguinet F" first="Francois" last="Haguinet">Francois Haguinet</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Schuind, Anne" sort="Schuind, Anne" uniqKey="Schuind A" first="Anne" last="Schuind">Anne Schuind</name>
</region>
<name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/GrippeCanadaV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000046 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000046 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    GrippeCanadaV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29548608
   |texte=   Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network).
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29548608" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeCanadaV3

This area was generated with Dilib version V0.6.35.
Data generation: Tue Jul 7 13:36:58 2020. Site generation: Sat Sep 26 07:06:42 2020

	Corpus GrippeCanadaV3
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Corpus GrippeCanadaV3

Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network).

Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network).

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki